Azathioprine: old drug, new actions.
نویسندگان
چکیده
منابع مشابه
Sensitive and spectrophotometric methods for the determination of Azathioprine in tablets using indigo carmine and methyl orange
A simple, economical, precise and fast visible spectrophotometric method has been developed for the determination of Azathioprine in tablet dosage form. Developed method is based on the formation of extractable colored complex of drug with colouring agent Indigo Carmine and Methyl orange. A wavelength maximum was found to be 683.7 nm and 566 nm. The concentration range of 15-50 μg mL-1 with of ...
متن کاملLeucocytoclastic vasculitis in a patient with azathioprine hypersensitivity.
We report the case of a 77-year-old man admitted nine days after being commenced on azathioprine with symptoms initially thought to be secondary to sepsis but in fact due to azathioprine hypersensitivity. He developed histologically proven cutaneous leucocytoclastic vasculitis following the re-introduction of azathioprine. We review the literature concerning adverse reactions to azathioprine an...
متن کاملThe relation between Thiopurine Methyl Transferase activity and efficacy and side effects of Azathioprine in patients with Pemphigus Vulgaris
Background and aim: Azathioprine is the most widely used immunosuppressive agent as an adjunct to corticosteroids in the treatment of pemphigus vulgaris (PV). Thiopurine methyl transferase (TPMT) is a key enzyme in azathioprine metabolism and a genetic polymorphism controls its activity in human tissue. TPMT activity can provide a rational basis to determine suitable dose of azathioprine, theor...
متن کاملAzathioprine hypersensitivity presenting as cardiogenic shock and Sweet's syndrome in a patient with microscopic polyangiitis.
Azathioprine hypersensitivity is a clinical syndrome which may manifest from isolated fever and rash to multi-organ failure. This rare condition is usually self-limiting following the discontinuation of azathioprine. Therefore, it is important to maintain a high index of clinical suspicion for hypersensitivity reactions with azathioprine therapy. We report a case of azathioprine hypersensitivit...
متن کاملAzathioprine induced anagen effluvium and its association with myelosuppression
Dear Editor, Azathioprine, a steroid sparing immunosuppressant, is used in organ transplantation and various immunological diseases like pemphigus vulgaris, pemphigus foliaceous, vitiligo, lichen planus, and alopecia areata. Anagen effluvium (AE) is the abrupt loss of hairs in their growing phase most commonly due to chemotherapy and radiation 1. Azathioprine can cause AE in association with my...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 111 8 شماره
صفحات -
تاریخ انتشار 2003